Expression of dystrophin in the mouse myenteric neurones.
Neurosci Lett
; 300(2): 120-4, 2001 Mar 09.
Article
en En
| MEDLINE
| ID: mdl-11207389
Dystrophin, a membrane-associated protein, plays relevant roles in cell functions. Its lack or trunkated expression results in Duchenne muscular dystrophy (DMD), a pathology associated with alterations in gastrointestinal motility considered to be neural in origin. No data are available on the presence of dystrophin in myenteric neurones. We labelled mouse myenteric neurones with DYS1-, DYS2-, DYS3-antibodies; staining was located on the perikarya and processes, with no differences in distribution or intensity among the antibodies; the western immunoblot analysis indicated that myenteric neurones express several dystrophin isoforms; anti-dystrophins/anti-neuronal specific enolase double-labeling confirmed that all neurones express dystrophin. Dystrophin in myenteric neurones might play a role in cytoskeletal organization, axonal transport and signal pathways; its lack might cause the intestinal motor abnormalities reported in DMD patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Distrofina
/
Sistema Digestivo
/
Motilidad Gastrointestinal
/
Plexo Mientérico
/
Neuronas
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Irlanda