Intrapallidal D2 dopamine receptors control globus pallidus neuron activity in the rat.
Neurosci Lett
; 300(2): 79-82, 2001 Mar 09.
Article
en En
| MEDLINE
| ID: mdl-11207379
Because activation of D2 dopamine receptors inhibits gamma-aminobutyric acid (GABA) release from intrapallidal nerve terminals, we measured the effects of modifiers of dopamine D2 receptors on the firing rate of single neurons in the globus pallidus (GP) of the anesthetized rat. The predominant effect of intrapallidal administration of the selective D2 agonist quinpirole was an increase in the rate of spontaneous firing while the D2 blocker sulpiride caused a decrease. The spontaneous firing of GP neurons is inhibited by stimulation of the GABAergic striatopallidal projection. We therefore measured the effects of modifiers of D2 receptors on striatal inhibition of GP neurons and found that intrapallidal quinpirole blocked the inhibitory effects of striatal stimulation while sulpiride enhanced them. These experiments show that both the spontaneous rate of firing of pallidal neurons and its modification by striatopallidal inputs is controlled by intrapallidal dopamine D2 receptors. In addition, taken together with other findings in the literature, our results suggest that activation of dopamine D2 receptors within the globus pallidus leads to inhibition of GABA release from presynaptic terminals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potenciales de Acción
/
Receptores de Dopamina D2
/
Terminales Presinápticos
/
Ácido gamma-Aminobutírico
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Globo Pálido
/
Inhibición Neural
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Irlanda