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The architecture of active zone material at the frog's neuromuscular junction.
Harlow, M L; Ress, D; Stoschek, A; Marshall, R M; McMahan, U J.
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  • Harlow ML; Department of Neurobiology, Stanford University School of Medicine, California 94305, USA.
Nature ; 409(6819): 479-84, 2001 Jan 25.
Article en En | MEDLINE | ID: mdl-11206537
Active zone material at the nervous system's synapses is situated next to synaptic vesicles that are docked at the presynaptic plasma membrane, and calcium channels that are anchored in the membrane. Here we use electron microscope tomography to show the arrangement and associations of structural components of this compact organelle at a model synapse, the frog's neuromuscular junction. Our findings indicate that the active zone material helps to dock the vesicles and anchor the channels, and that its architecture provides both a particular spatial relationship and a structural linkage between them. The structural linkage may include proteins that mediate the calcium-triggered exocytosis of neurotransmitter by the synaptic vesicles during synaptic transmission.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Unión Neuromuscular Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nature Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Unión Neuromuscular Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nature Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido