Your browser doesn't support javascript.
loading
Relationship between plasma ammonia concentration and beta-N-acetylhexosaminidase isoenzyme activities in liver cirrhosis.
Pérez, L F; Casal, J A; Rojas, P; Tutor, J C.
Afiliación
  • Pérez LF; Laboratorio Central, Hospital Clinico Universitario, Santiago de Compostela, Spain.
Clin Chem Lab Med ; 38(12): 1237-41, 2000 Dec.
Article en En | MEDLINE | ID: mdl-11205687
Ammonia is known to increase the secretion of beta-N-acetylhexosaminidase (Hex) to the extracellular medium in cultured human fibroblasts and Hep G2 cells. We examined 35 patients with liver cirrhosis and the results revealed a significant increase for the plasma activities of total Hex and its isoenzymes Hex A and Hex B (p < 0.001). The partial correlations, with other biochemical markers of liver injury constant, between plasma ammonia concentration and the activity (r = 0.658) and the proportion in percentage of the Hex B isoenzyme (r = 0.692) were statistically significant (p < 0.001). The increased concentration of ammonia could explain, at least partially, an increased secretion of Hex B isoforms to the plasma in patients with liver disease.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Amoníaco / Isoenzimas / Cirrosis Hepática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2000 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Amoníaco / Isoenzimas / Cirrosis Hepática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2000 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania