[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis].

Gushchin, A E; Ladygina, V G; Govorun, V M; Taraskina, A M; Savicheva, A M

[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis]. / Analiz raionov, opredeliaiushchikh rezistentnost' k ftorkhinolonam, genov gyrA i parC v klinicheskikh izoliatakh Mycoplasma hominis.

Gushchin, A E; Ladygina, V G; Govorun, V M; Taraskina, A M; Savicheva, A M.

Afiliación

Gushchin AE; Laboratory of Gene Engineering and Immunogenetics, Institute of Physico-Chemical Medicine, Ministry of Health of Russian Federation, Moscow, St. Petersburg.

Mol Gen Mikrobiol Virusol ; (4): 33-5, 2000.

Article en Ru | MEDLINE | ID: mdl-11186458

RESUMEN

Fifteen strains of M. hominis isolated from patients with urogenital inflammations were analyzed. Variations in the quinolone resistance-determining regions (QRDR) have been found in fluoroquinolone-resistant M. hominis clinical isolates in comparison with the reference PG21 strain. In one isolate, parC had Asn substitute at position 91.

Asunto(s)

Antiinfecciosos/farmacología; ADN-Topoisomerasas de Tipo II/genética; Farmacorresistencia Microbiana/genética; Mycoplasma hominis/efectos de los fármacos; Secuencia de Bases; Girasa de ADN; Cartilla de ADN; Topoisomerasa de ADN IV; Fluoroquinolonas; Mycoplasma hominis/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacorresistencia Microbiana / ADN-Topoisomerasas de Tipo II / Mycoplasma hominis / Antiinfecciosos Idioma: Ru Revista: Mol Gen Mikrobiol Virusol Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA / VIROLOGIA Año: 2000 Tipo del documento: Article Pais de publicación: Rusia

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