Nerve growth factor in neurological and non-neurological diseases: basic findings and emerging pharmacological prospectives.
Curr Pharm Des
; 7(2): 113-23, 2001 Jan.
Article
en En
| MEDLINE
| ID: mdl-11172703
Nerve growth factor (NGF) is known to be essential for the survival of peripheral and brain neurons, and according to more recent studies also for a variety of cells localized in the immune system. Basic and preclinical findings published in the last 15-20 years have prospected the hypothesis that NGF can be pharmaceutically useful for promoting healing in certain peripheral and central neurological insults. We have recently provided evidence that NGF applied topically, has a therapeutic potentiality for human corneal and pressure ulcers, and more recently in vasculitis induced by rheumatoid arthritis. This review will summarize previous and ongoing evidence supporting the role of NGF in the nervous and immune system and discuss NGF potentiality as a pharmacological tool for basic and clinical studies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento Nervioso
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Pharm Des
Asunto de la revista:
FARMACIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Emiratos Árabes Unidos