Lipophilic calcium antagonists in antiatherosclerotic therapy.
Curr Atheroscler Rep
; 2(1): 76-81, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-11122728
Two key events in atherosclerotic plaque formation are the deposition of lipids in cells of the vascular wall, and migration and proliferation of arterial smooth muscle cells from the tunica intima toward the media. It has been shown that various calcium-channel antagonists may delay plaque formation in animal models. Among these, the new and highly lipophilic calcium antagonists, such as lacidipine and lercanidipine, display the most promising antiatherosclerotic activities. This paper will review and discuss these beneficial effects.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Dihidropiridinas
/
Bloqueadores de los Canales de Calcio
Límite:
Humans
Idioma:
En
Revista:
Curr Atheroscler Rep
Asunto de la revista:
ANGIOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Estados Unidos