Evaluation of current activities of fluoroquinolones against gram-negative bacilli using centralized in vitro testing and electronic surveillance.

Sahm, D F; Critchley, I A; Kelly, L J; Karlowsky, J A; Mayfield, D C; Thornsberry, C; Mauriz, Y R; Kahn, J

Sahm, D F; Critchley, I A; Kelly, L J; Karlowsky, J A; Mayfield, D C; Thornsberry, C; Mauriz, Y R; Kahn, J.

Afiliación

Sahm DF; MRL, Herndon, Virginia 20171, USA. dsahm@mrlinfo.com

Antimicrob Agents Chemother ; 45(1): 267-74, 2001 Jan.

Article en En | MEDLINE | ID: mdl-11120976

RESUMEN

Given the propensity for Enterobacteriaceae and clinically significant nonfermentative gram-negative bacilli to acquire antimicrobial resistance, consistent surveillance of the activities of agents commonly prescribed to treat infections arising from these organisms is imperative. This study determined the activities of two fluoroquinolones, levofloxacin and ciprofloxacin, and seven comparative agents against recent clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia using two surveillance strategies: 1) centralized in vitro susceptibility testing of isolates collected from 27 hospital laboratories across the United States and 2) analysis of data from The Surveillance Network Database-USA, an electronic surveillance network comprising more than 200 laboratories nationwide. Regardless of the surveillance method, Enterobacteriaceae, P. aeruginosa, and A. baumannii demonstrated similar rates of susceptibility to levofloxacin and ciprofloxacin. Susceptibilities to the fluoroquinolones approached or exceeded 90% for all Enterobacteriaceae except Providencia spp. (

Asunto(s)

Antiinfecciosos/farmacología; Bacterias Gramnegativas/efectos de los fármacos; Infecciones por Bacterias Gramnegativas/epidemiología; Infecciones por Bacterias Gramnegativas/microbiología; Resistencia a las Cefalosporinas; Bases de Datos Factuales; Resistencia a Múltiples Medicamentos; Fluoroquinolonas; Humanos; Pruebas de Sensibilidad Microbiana; Estados Unidos/epidemiología; Resistencia betalactámica

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Bacterias Gramnegativas / Bacterias Gramnegativas / Antiinfecciosos Tipo de estudio: Screening_studies Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Antimicrob Agents Chemother Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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