Your browser doesn't support javascript.
loading
A family of compact plasmid vectors for DNA immunization in humans.
Herrera, A M; Rodríguez, E G; Hernández, T; Sández, B; Duarte, C A.
Afiliación
  • Herrera AM; Division of Vaccines, Centro de Ingeniería Genética y Biotecnología, Apartado Postal 6162, Havana, 10 600, Cuba. amherrera@cigb.edu.cu
Biochem Biophys Res Commun ; 279(2): 548-51, 2000 Dec 20.
Article en En | MEDLINE | ID: mdl-11118323
DNA immunization technology is based on the availability of adequate vectors for cloning and expression of heterologous immunoactive proteins in mammalian cells. We have developed a family of DNA plasmid vectors suitable to manipulate antigen expression and location. Their in vitro and in vivo functionality and application are also reported. The developed immune response, the aspects considered for vector design, and the possible independent manipulation of both blocks for the generation of bicistronic constructs, make of the pAEC family of plasmid vectors a source for DNA vaccine candidate's development for further evaluation in human clinical trials, and for potential use in the gene therapy approach.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásmidos / Vacunas de ADN / Vectores Genéticos Límite: Animals / Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2000 Tipo del documento: Article País de afiliación: Cuba Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plásmidos / Vacunas de ADN / Vectores Genéticos Límite: Animals / Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2000 Tipo del documento: Article País de afiliación: Cuba Pais de publicación: Estados Unidos