Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction.

Naber, C K; Hüsing, J; Wolfhard, U; Erbel, R; Siffert, W

Naber, C K; Hüsing, J; Wolfhard, U; Erbel, R; Siffert, W.

Afiliación

Naber CK; Abteilung für Kardiologie, Institut für Medizinische Informatik, Biometrie und Epidemiologie, Abteilung für Thorax- und Kardiovaskuläre Chirurgie, Universitätsklinikum Essen, Germany. christoph.naber@uni-essen.de

Hypertension ; 36(6): 986-9, 2000 Dec.

Article en En | MEDLINE | ID: mdl-11116112

RESUMEN

In polygenetic disorders, such as ischemic heart disease, the investigation of gene-gene interactions rather than determination of single gene effects is crucial to better understand the contribution of genetic factors. The 825T allele of the G-protein ss(3)-subunit gene (GNB3) associated with enhanced G-protein signaling is a candidate to interact with the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism to increase the risk for myocardial infarction (MI). The ACE D:/I variant affects the renin-angiotensin system hormones that activate G-protein-coupled receptors. Genotyping at the ACE and GNB3 loci was performed on 585 patients with coronary artery disease with (n=270) or without (n=315) previous MI. Logistic regression analysis demonstrated a significant interaction between the ACE D: allele and the GNB3 825T allele (P<0.001). The odds ratio for MI, associated with the 825T allele, was not increased in the presence of the ACE II genotype (OR 0.5; P=0.09) but was significantly higher in 825T allele carriers with the ACE DI genotype (OR 1.9; P=0.01) and further increased in individuals with the ACE DD genotype (OR 2.4; P=0.02). The highest odds ratio was found in homozygous 825T allele carriers with the ACE DD genotype (OR 7.5; P=0.006). Our data suggest a significant interaction of the GNB3 825T allele with the ACE D allele in MI. These hypothesis-generating data may justify larger prospective studies.

Asunto(s)

Proteínas de Unión al GTP Heterotriméricas/genética; Infarto del Miocardio/genética; Peptidil-Dipeptidasa A/genética; Anciano; Alelos; Angiografía; Enfermedad Coronaria/genética; Femenino; Eliminación de Gen; Genotipo; Proteínas de Unión al GTP Heterotriméricas/metabolismo; Humanos; Masculino; Persona de Mediana Edad; Peptidil-Dipeptidasa A/metabolismo; Factores de Riesgo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peptidil-Dipeptidasa A / Proteínas de Unión al GTP Heterotriméricas / Infarto del Miocardio Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Año: 2000 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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