Characterisation of an endogenous bombesin receptor in CHO/DG44 cells.
Eur J Pharmacol
; 409(3): 259-63, 2000 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-11108819
Bombesin and its receptors have been shown to have a role regulating circadian rhythms in the hamster suprachiasmatic and dorsal raphe nuclei and have been implicated in the regulation of sleep. We have identified and characterised a bombesin receptor endogenously expressed in a Chinese hamster ovary cell line (CHO/DG44). Using a range of bombesin-like peptides, we demonstrate that this receptor displays bombesin BB2 receptor-like pharmacology. We also show that this receptor signals through inositol-[1,4,5]-trisphosphate and protein kinase C and thus provides a useful model system to aid in the interpretation of hamster suprachiasmatic nucleus studies of mammalian circadian rhythm.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bombesina
/
Células CHO
/
Receptores de Bombesina
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
2000
Tipo del documento:
Article
Pais de publicación:
Países Bajos