The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins.

Uhl, G R; Li, S; Takahashi, N; Itokawa, K; Lin, Z; Hazama, M; Sora, I

Uhl, G R; Li, S; Takahashi, N; Itokawa, K; Lin, Z; Hazama, M; Sora, I.

Afiliación

Uhl GR; Molecular Neurobiology Branch, NIDA-IRP, National Institutes of Health, Baltimore, Maryland 21224, USA. guhl@intra.nida.nih.gov

FASEB J ; 14(15): 2459-65, 2000 Dec.

Article en En | MEDLINE | ID: mdl-11099463

RESUMEN

Monoamine compartmentalization in monoaminergic neurons uses serial action of the plasma membrane and vesicular monoamine (VAMT2) transporters. We can now define the sequences of the genes encoding these transporters in mice and humans, examine influences of deletions of this gene and alteration in its expression levels in transgenic mice, and identify sequence polymorphisms in the human VMAT2 gene. Examination of VMAT2 variants can provide potential insights into roles for allelic variants at these loci in variant drug responses and in diseases linked to monoaminergic systems, including substance abuse and Parkinson's disease.

Asunto(s)

Glicoproteínas de Membrana/genética; Proteínas de Transporte de Membrana; Neuropéptidos; Envejecimiento/genética; Anfetaminas/farmacología; Animales; Arritmias Cardíacas/genética; Humanos; Intoxicación por MPTP/genética; Ratones; Polimorfismo Genético; Ratas; Proteínas de Transporte Vesicular de Aminas Biógenas; Proteínas de Transporte Vesicular de Monoaminas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Neuropéptidos / Glicoproteínas de Membrana Límite: Animals / Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2000 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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