Treatment of postkeratitis fusarium endophthalmitis with amphotericin B lipid complex.
Cornea
; 19(6): 853-6, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11095064
PURPOSE: The authors report the first case of Fusarium solani keratitis that progressed to fungal endophthalmitis and was successfully treated with amphotericin B lipid complex (ABLC). METHOD: The case of a 34-year-old immunocompetent woman who developed a contact lens-related F. solani keratitis requiring emergency penetrating keratoplasty (PKP) was analyzed. The immunocompetent patient developed fungal endophthalmitis (anterior chamber tap positive for F. solani three months after PKP) and was eventually treated with ABLC. RESULTS: Systemic amphotericin B (total, 0.42 g) and ketoconazole in addition to topical natamycin and amphotericin did not prove to be effective in eradicating the mycosis in the anterior chamber. Under ABLC treatment (total, 8.79 g), the anterior chamber inflammation resolved completely. No recurrence was observed during an 11-month follow-up after treatment was discontinued. CONCLUSION: ABLC proved to be effective in treating F. solani endophthalmitis. It is an important addition to the ophthalmic armamentarium, and appeared to be a better therapeutic agent than standard amphotericin B in this patient.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfatidilcolinas
/
Fosfatidilgliceroles
/
Infecciones Fúngicas del Ojo
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Anfotericina B
/
Endoftalmitis
/
Fusarium
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Queratitis
/
Micosis
/
Antifúngicos
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Cornea
Año:
2000
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Estados Unidos