Histological observations of palatal malformations in rat embryos induced by retinoic acid treatment.
Exp Toxicol Pathol
; 52(5): 437-44, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11089895
Malformations of the palate were induced in white rat embryos following maternal exposure to retinoic acid (tretinoin). Five experimental groups and the controls were treated by the following protocol: Group 1: pregnant rats received 100 mg retinoic acid (RA)/kg b.w. suspended in corn oil on gestational day (GD) 11.5; Group 2: 20 mg RA/kg b.w. from GD 8-12; Group 3: 20 mg RA/kg b.w. from GD 7.5-11.5; Group 4: 100 mg RA/kg b.w. on GD 10-11; Group 5: 100 mg RA/kg b.w. on GD 10 and 12; Group 6 received corn oil vehicle from GD 7-14.5; and Group 6: served as non-injected controls. In all retinoic acid treated groups, varying degrees of clefts with occasional attempts of fusion were noted. The severity and frequency of the malformations were dependent on dosage or gestational day of drug treatment. Our results indicate that RA, even at the lowest dose tested (20 mg/kg b.w.) severely affects the various tissues constituting the embryonic palatal shelves by altering cell interaction and possibly programmed cell death. These events would then result in lack of or inadequate differentiation with subsequent formation of aberrant craniofacial architecture.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hueso Paladar
/
Tretinoina
/
Anomalías Inducidas por Medicamentos
Tipo de estudio:
Guideline
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Exp Toxicol Pathol
Asunto de la revista:
PATOLOGIA
/
TOXICOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Grecia
Pais de publicación:
Alemania