Enhanced safety and efficacy of live attenuated SIV vaccines by prevaccination with recombinant vaccines.
J Med Primatol
; 29(3-4): 231-9, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-11085585
The only vaccines shown to be protective against intravenous challenge with virulent virus in the simian immunodeficiency virus (SIV)/macaque model are attenuated live SIVs. However, these vaccines have several disadvantages: 1) they persist indefinitely in vaccinated macaques; 2) they are pathogenic to neonatal macaques; and 3) they are lethal in some adult macaques. To enhance the safety and efficacy of these vaccines, we immunized macaques first with recombinant vaccines and then inoculated the animals with SIV(delta(nef)). In the first experiment, preimmunized macaques advanced to disease slower than controls after challenge with virulent SIV; five animals survived for 3 years without disease and only the vaccine virus (SIV(delta(nef)) could be isolated at this time. In the second experiment, preimmunized animals had lower virus loads and no disease compared to controls.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Atenuadas
/
Vacunas Sintéticas
/
Linfocitos
/
Síndrome de Inmunodeficiencia Adquirida del Simio
/
Virus de la Inmunodeficiencia de los Simios
/
Vacunas contra el SIDAS
Límite:
Animals
Idioma:
En
Revista:
J Med Primatol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Dinamarca