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Thyroid hormones and lipid metabolism in a group of patients over seventy.
Maugeri, D; Santangelo, A; Barbagallo, P; Bonanno, M R; Malaguarnera, M; Rizza, I; Speciale, S; Tomarchio, M; Curasì, M P; Panebianco, P.
Afiliación
  • Maugeri D; Institute of Internal Medicine and Geriatrics University of Catania, Italy.
Eur Rev Med Pharmacol Sci ; 3(5): 211-6, 1999.
Article en En | MEDLINE | ID: mdl-11075619
Numerous studies have suggested a marked correlation between thyroid functionality indices and lipid metabolism. In this trial we assessed the functional parameters of 165 individuals over 70, 87 women and 78 men, correlating the serum values of T3, T4, FT4, TSH with cholesterol, triglycerides, HDL, Apo-A and Apo-B levels. The correlation was performed over the whole population studied and subsequently, after dividing the population by sex and age (3 age groups: A, 70-75; B, 76-80; C, over 80) in the individual groups. In the population as a whole, we have observed a statistically significant correlation between T4/cholesterol (P=0.0001); T3/cholesterol (P=0.06); T4/triglycerides (P=0.0001); T3/triglycerides (P=0.09); T4/HDL (P=0.0001); T4/Apo-A (P= 0.02); T3/Apo-A (P=0.008); T4/Apo-B (P=0.0001). Analysis by gender shows a statistically significance between the female and male sexes in the correlation between T3/cholesterol (P=0.001); T3/triglycerides (P=0.06); T4/cholesterol (P=0.0001) and T4/triglycerides (P=0.0001). When the data were analyzed by age, in Group A (75-80) there was no statistically significant correlation, whereas in Group B (76-80) there has been an increase in significance in the correlation between T3/cholesterol (P=0.006); T3/triglycerides (P=0.001); T3/Hdl (P=0.08); T3/Apo-A (P=0.0001); T3/Apo-B (P=0.08); T4/cholesterol (P=0.00001) and ); T4/Apo-A (P=0.0001). On the other hand in the Group C age group (over 80) this significance is considerably lower. Maybe this decrease of correlations should be attributed to a global savings of the older organisms, or to a process of natural selection.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormonas Tiroideas / Anciano / Metabolismo de los Lípidos Límite: Female / Humans / Male Idioma: En Revista: Eur Rev Med Pharmacol Sci Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormonas Tiroideas / Anciano / Metabolismo de los Lípidos Límite: Female / Humans / Male Idioma: En Revista: Eur Rev Med Pharmacol Sci Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia