The epigenetics of nucleolar dominance.
Trends Genet
; 16(11): 495-500, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11074291
Epigenetic phenomena are heritable, alternative states of gene activity that are not explained by mutation, changes in gene sequence or normal developmental regulation. Among the earliest examples was nucleolar dominance, a common phenomenon in interspecific hybrids in which only ribosomal RNA (rRNA) genes inherited from one parent are transcribed. Only active rRNA genes initiate formation of a nucleolus, hence the name for the phenomenon. As in other epigenetic phenomena, chromatin modifications enforce selective gene silencing in nucleolar dominance. However, the mechanisms that discriminate between parental sets of rRNA genes are unclear. Possibilities include sequence differences that affect transcription factor affinities. Other evidence suggests that chromosomal context is more important than rRNA gene sequences, implying control on a larger scale.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nucléolo Celular
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido