Fungi test for evaluation of new antiandrogenic molecule.
Proc West Pharmacol Soc
; 43: 29-30, 2000.
Article
en En
| MEDLINE
| ID: mdl-11056949
Antiandrogens have high impact in medicine as they are compounds capable of decreasing the effect of benign prostatic hyperplasia, cancer, and other androgen-dependent diseases that affect a large percentage of the male population in the world. [figure: see text] Dihydrotestosterone, a 5 alpha-reductase metabolite of testosterone, has been implicated as the responsible factor of these androgen abnormalities. This fact indicates that the logical step in the treatment of these diseases is the inhibition of this enzyme activity using molecules that compete selectively with its natural substrates. The study of the pharmacological effect of antiandrogens requires specific animal models using a large number of laboratory animals. On basis of this concept, presently there is a tendency to eliminate studies with animals. In this paper we report a new method for antiandrogenic evaluation using microbial transformations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicillium
/
Antagonistas de Andrógenos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Proc West Pharmacol Soc
Año:
2000
Tipo del documento:
Article
Pais de publicación:
Estados Unidos