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Detection of biomarkers for apoptosis in rat liver after perfusion with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).
Ashida, H; Kihara, K; Shiotani, B; Hashimoto, T; Kanazawa, K; Danno, G.
Afiliación
  • Ashida H; Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Japan. ashida@kobe-u.ac.jp
Biosci Biotechnol Biochem ; 64(9): 2021-4, 2000 Sep.
Article en En | MEDLINE | ID: mdl-11055418
We previously demonstrated that 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induced apoptosis in primary cultured rat hepatocytes. In this study, we investigated apoptotic biomarkers in rat liver after perfusion with 30 microM Trp-P-1 as preliminary experiments for in vivo study. Induction of c-Myc and p53 protein and the activities of caspase-3, -6, and -8 were detected in Trp-P-1-perfused liver. In addition, Trp-P-1 modulated the DNA binding activity of the apoptosis-related transcription factors, NF-kappaB and AP-1. These results imply a possibility that Trp-P-1 would induce apoptosis in vivo.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbolinas / Apoptosis / Caspasas / Hígado / Mutágenos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2000 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbolinas / Apoptosis / Caspasas / Hígado / Mutágenos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2000 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido