Rectosigmoidal adenomatous polyposis: a novel entity of polyposis? Report of a case.
Dis Colon Rectum
; 43(10): 1439-43, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11052523
PURPOSE: We report a patient with rectosigmoidal adenomatous polyposis. METHODS: A 57-year-old male presented with a submucosally invasive well-differentiated adenocarcinoma in the rectum and approximately 100 adenomatous polyps with an extremely unusual distribution limited exclusively to the rectum and sigmoid colon. RESULTS: There was no family history of colorectal disease or any related disorders. No extracolonic manifestations were found. Because this case was considered to be a discriminative phenotype of familial adenomatous polyposis, DNA from a peripheral sample of whole blood was screened for APC germline mutation by a combination of protein truncation test and single stranded conformation polymorphism, but no mutation was found. CONCLUSION: This patient may have a novel entity of adenomatous polyposis with a peculiar distribution. It may be caused by some genetic alteration other than APC mutation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Recto
/
Neoplasias del Colon Sigmoide
/
Poliposis Adenomatosa del Colon
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dis Colon Rectum
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos