[Comparative study of isosorbide dinitrates and mononitrates in patients with ischemic heart disease and stable angina pectoris caused by stenosing coronary atherosclerosis]. / Sravnitel'noe izuchenie izosorbida di- i mononitratov u bol'nykh ishemicheskoi bolezn'iu serdtsa so stabil'noi stenokardiei, obuslovlennoi stenoziruiushim koronarnym aterosklerozom.
Klin Med (Mosk)
; 78(9): 52-5, 2000.
Article
en Ru
| MEDLINE
| ID: mdl-11051743
In an open clinical trial 19 patients with angina pectoris (functional class II-III) received in turn either non-retard tablets of isosorbide dinitrate (nitrosorbid, cardiket) in a mean dose 80 mg/day or isosorbide 5-mononitrate (mono mac) in a mean dose 51.5 mg/day. Each drug was given for a month. The effect was assessed by changes in frequency of anginal attacks and exercise tolerance. Non-retard isosorbide dinitrate and isosorbide 5-mononitrate demonstrate a good antiischemic effect, are safe and well tolerated. Isosorbide dinitrate and mononitrates do not differ significantly in reduction of the anginal attacks and by an increase in exercise tolerance but the effective dose of mono mac was 1.5-2 times less than that of nitrosorbide or cardiket, thus it is more cost-effective.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasodilatadores
/
Enfermedad de la Arteria Coronaria
/
Isquemia Miocárdica
/
Enfermedad Coronaria
/
Dinitrato de Isosorbide
/
Angina de Pecho
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Klin Med (Mosk)
Año:
2000
Tipo del documento:
Article
Pais de publicación:
Rusia