Mechanisms involved in the hemodynamic alterations in congestive heart failure as a basis for a rational pharmacological treatment.
Pharmacol Ther
; 88(1): 15-31, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11033382
Congestive heart failure is a complex syndrome and one of the major cardiological problems of our time. It is characterized by an important neurohumoral activation to compensate for the reduction of cardiac output and blood pressure, that worsens the prognosis with time. The aim of the treatment is focused on how to improve the quality of life and how to prolong survival. Usually, treatment, either symptomatic or directed to control the neuroendocrine compensatory changes, is necessary. The drugs currently used are angiotensin-converting enzyme inhibitors, diuretics, digoxin, and beta-adrenoceptor agonists. In addition, new drugs, such as angiotensin II receptor antagonists, beta-adrenoceptor antagonists, ibopamine, Ca(2+) antagonists, neutral endopeptidase inhibitors, vasopressin antagonists, Ca(2+)-sensitizers with cyclic AMP-dependent or -independent mechanisms, and endothelin antagonists, are also being used.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fármacos Cardiovasculares
/
Insuficiencia Cardíaca
/
Hemodinámica
Aspecto:
Patient_preference
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Ther
Año:
2000
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Reino Unido