An improved synthesis of functionalized biphenyl-based phosphine ligands.
J Org Chem
; 65(17): 5334-41, 2000 Aug 25.
Article
en En
| MEDLINE
| ID: mdl-10993363
Functionalized dicyclohexyl- and di-tert-butylphosphinobiphenyl ligands are prepared by the reaction of arylmagnesium halides with benzyne, followed by the addition of a chlorodialkylphosphine. This one-pot procedure is considerably less expensive and time-consuming than the method used previously to prepare such ligands. The cost of introducing the dicyclohexylphosphine group can be decreased by preparing chlorodicyclohexylphosphine from PCl3 and cyclohexylmagnesium chloride, and using the reagent without further purification. The new method is significant, as a variety of ligands can be produced in useful amounts by a procedure that is simple, with starting materials that are relatively inexpensive, and, in most cases, without chromatographic purification.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfinas
/
Compuestos de Bifenilo
Idioma:
En
Revista:
J Org Chem
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos