Inhibitory activity of flavonoids and tannins against HIV-1 protease.
Biol Pharm Bull
; 23(9): 1072-6, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-10993207
Twenty-nine flavonoids and six hydrolyzable tannins were studied for their inhibitory activity against human immunodeficiency virus (HIV)-1 protease using fluorescence and HPLC assays. Among the flavonoids, flavones, flavanones, flavonols, catechols and chalcones, the flavonols were the most active category while flavanones and catechols displayed low activity. Quercetin was the most potent inhibitor of the target enzyme with an IC50 value of 58.8 microM, while butein and luteolin showed moderate activity. Of the hydrolyzable tannins tested, three ellagitannins which contain a hexahydroxvdiphenoyl (HHDP) unit linked to the O-3 and 0-6 positions of the sugar, were found to strongly inhibit HIV-1 protease. The IC50 values of corilagin and repandusinic acid on HIV-1 protease were 20.7 and 12.5 microM, respectively.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Taninos
/
Flavonoides
/
Proteasa del VIH
/
Inhibidores de la Proteasa del VIH
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2000
Tipo del documento:
Article
Pais de publicación:
Japón