Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

Barlic, J; Andrews, J D; Kelvin, A A; Bosinger, S E; DeVries, M E; Xu, L; Dobransky, T; Feldman, R D; Ferguson, S S; Kelvin, D J

Barlic, J; Andrews, J D; Kelvin, A A; Bosinger, S E; DeVries, M E; Xu, L; Dobransky, T; Feldman, R D; Ferguson, S S; Kelvin, D J.

Afiliación

Barlic J; Laboratory of Molecular Immunology and Inflammation, John P. Robarts Research Institute, 1400 Western Road, London, Ontario, Canada, N6G 2V4.

Nat Immunol ; 1(3): 227-33, 2000 Sep.

Article en En | MEDLINE | ID: mdl-10973280

RESUMEN

Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCRI was found to stimulate rapid formation of beta-arrestin complexes with Hck or c-Fgr. Formation of beta-arrestin-Hck complexes led to Hck activation and trafficking of the complexes to granule-rich regions. Granulocytes expressing a dominant-negative beta-arrestin-mutant did not release granules or activate tyrosine kinases after IL-8 stimulation. Thus, beta-arrestins regulate chemokine-induced granule exocytosis, indicating a broader role for beta-arrestins in the regulation of cellular functions than was previously suspected.

Asunto(s)

Arrestinas/fisiología; Gránulos Citoplasmáticos/metabolismo; Proteínas Tirosina Quinasas/metabolismo; Receptores de Interleucina-8A/fisiología; Secuencia de Aminoácidos; Arrestinas/genética; Arrestinas/metabolismo; Degranulación de la Célula; Activación Enzimática; Granulocitos/inmunología; Granulocitos/metabolismo; Humanos; Interleucina-8/farmacología; Datos de Secuencia Molecular; Proteínas Tirosina Quinasas/fisiología; Proteínas Proto-Oncogénicas/metabolismo; Proteínas Proto-Oncogénicas/fisiología; Proteínas Proto-Oncogénicas c-hck; Receptores de Interleucina-8A/genética; Receptores de Interleucina-8A/metabolismo; Transfección; beta-Arrestinas; Familia-src Quinasas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Arrestinas / Receptores de Interleucina-8A / Gránulos Citoplasmáticos Límite: Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2000 Tipo del documento: Article Pais de publicación: Estados Unidos

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