6-Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted withibuprofen: synthesis, characterization and evaluation of anti-inflammatory activity.
Eur J Med Chem
; 35(7-8): 743-50, 2000.
Article
en En
| MEDLINE
| ID: mdl-10960191
In this study, the synthesis of 3-[1-(4-(2-methylpropyl)phenyl)ethyl]-1,2,4-triazole-5-thione (2) and its condensed derivatives 6-benzylidenethiazolo[3,2-b]-1,2, 4-triazole-5(6H)-ones (2a-u) are described. The structures of the compounds were elucidated by spectral and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened. Among the compounds examined, the compounds 2 and 2g possessed the most prominent and consistent activity. In gastric ulceration studies the synthesized compounds were generally found to be safe at a 200 mg/kg dose level.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triazoles
/
Antiinflamatorios no Esteroideos
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2000
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Francia