Immune, endocrine, and psychological responses in civilians displaced by war.
Psychosom Med
; 62(4): 502-8, 2000.
Article
en En
| MEDLINE
| ID: mdl-10949095
OBJECTIVES: The objectives of this study were to assess the influence of trauma caused by forced expulsion from home in a war-ravaged region on the psychological, hormonal, and immune responses in displaced persons and to analyze the relationships between psychometric, hormonal, and immunologic variables. METHODS: Participants were 20 displaced and 14 control women. Psychosomatic response was evaluated using the COR-NEX2 test. Serum concentrations of cortisol, prolactin, endorphin, thyroxine, and triiodothyronine were measured by radioimmunoassay. Immunophenotyping and lymphocyte proliferation were determined by flow cytometry, and phagocyte functions (i.e., ingestion and antibody-dependent cytotoxicity) against 51Cr-labeled sheep red blood cells were assessed through radioactivity uptake and release, respectively. RESULTS: In comparison with control women, displaced women had higher COR-NEX2 test scores; higher serum cortisol, prolactin, and endorphin levels; an increase in activated phenotype within all three measured cell populations (i.e., B, T, and natural killer cells); as well as an enhanced proportion of proliferating lymphocytes in freshly isolated samples. However, the phytohemagglutinin-stimulated proliferative response, estimated as the stimulation index, was lower in displaced women. A complex pattern of relations between psychological, hormonal, and immune responses was observed. CONCLUSIONS: Chronic psychological stress elicited multiple, predominantly stimulatory influences on immune functions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fagocitosis
/
Nivel de Alerta
/
Refugiados
/
Trastornos por Estrés Postraumático
/
Guerra
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Activación de Linfocitos
/
Hormonas
/
Citotoxicidad Celular Dependiente de Anticuerpos
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
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Adult
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Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Psychosom Med
Año:
2000
Tipo del documento:
Article
País de afiliación:
Croacia
Pais de publicación:
Estados Unidos