The role of the t-PA I/D and PAI-1 4G/5G polymorphisms in African-American adults with a diagnosis of myocardial infarction or venous thromboembolism.

Hooper, W C; Lally, C; Austin, H; Renshaw, M; Dilley, A; Wenger, N K; Phillips, D J; Whitsett, C; Rawlins, P; Evatt, B L

Hooper, W C; Lally, C; Austin, H; Renshaw, M; Dilley, A; Wenger, N K; Phillips, D J; Whitsett, C; Rawlins, P; Evatt, B L.

Afiliación

Hooper WC; Hematologic Disease Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. wohl@cdc/gov

Thromb Res ; 99(3): 223-30, 2000 Aug 01.

Article en En | MEDLINE | ID: mdl-10942788

RESUMEN

To determine whether or not the PAI-1 4G/5G and t-PA I/D polymorphisms in African-Americans were linked to cardiovascular disease, the association of these polymorphisms to disease expression was analyzed in a recently completed case-control study of myocardial infarction or venous thromboembolism among African-Americans. All African-Americans patients with a history of venous thromboembolism attending an anticoagulant clinic, and patients with a history of a MI attending a cardiology clinic at a large local urban public hospital were eligible for inclusion as cases in the study. In this study it was observed that there was a statistically significant association between the D allele of the t-PA I/D polymorphism and venous thromboembolism and a nonsignificant association between the D allele and myocardial infarction among African-Americans. t-PA antigen levels were statistically significantly higher among both myocardial infarction and venous thromboembolism cases compared with control subjects. The genotypes were unrelated to t-PA plasma levels. There was no association between either myocardial infarction or venous thromboembolism and the 4G/5G PAI-1 genotype. It was also found that genotype frequencies for both PAI-1 4G/5G and t-PA I/D polymorphisms in African-American adults were different from those reported for both U.S. Causcians and Europeans.

Asunto(s)

Población Negra/genética; Negro o Afroamericano; Infarto del Miocardio/etnología; Inhibidor 1 de Activador Plasminogénico/genética; Polimorfismo Genético; Regiones Promotoras Genéticas/genética; Activador de Tejido Plasminógeno/genética; Trombosis de la Vena/etnología; Adulto; Anciano; Anciano de 80 o más Años; Estudios de Casos y Controles; Femenino; Frecuencia de los Genes; Predisposición Genética a la Enfermedad; Genotipo; Georgia/epidemiología; Humanos; Masculino; Persona de Mediana Edad; Infarto del Miocardio/genética; Oportunidad Relativa; Riesgo; Trombosis de la Vena/genética

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Negro o Afroamericano / Regiones Promotoras Genéticas / Activador de Tejido Plasminógeno / Inhibidor 1 de Activador Plasminogénico / Trombosis de la Vena / Población Negra / Infarto del Miocardio Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Thromb Res Año: 2000 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links