Involvement of phospholipase D in store-operated calcium influx in vascular smooth muscle cells.
FEBS Lett
; 479(1-2): 51-6, 2000 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-10940387
In non-excitable cells, sustained intracellular Ca2+ increase critically depends on influx of extracellular Ca2+. Such Ca2+ influx is thought to occur by a 'store-operated' mechanism, i.e. the signal for Ca2+ entry is believed to result from the initial release of Ca2+ from inositol 1,4,5-trisphosphate-sensitive intracellular stores. Here we show that the depletion of cellular Ca2+ stores by thapsigargin or bradykinin is functionally linked to a phosphoinositide-specific phospholipase D (PLD) activity in cultured vascular smooth muscle cells (VSMC), and that phosphatidic acid formed via PLD enhances sustained calcium entry in this cell type. These results suggest a regulatory role for PLD in store-operated Ca2+ entry in VSMC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfolipasa D
/
Calcio
/
Músculo Liso Vascular
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Reino Unido