Xenotransplantation of microencapsulated bovine chromaffin cells into hemiparkinsonian monkeys.
Artif Cells Blood Substit Immobil Biotechnol
; 28(4): 337-45, 2000 Jul.
Article
en En
| MEDLINE
| ID: mdl-10928703
This study examines the effects of xenografts of microencapsulated bovine chromaffin cells (BCCs) on the rotational behavior of hemiparkinsonian monkey recipients. In addition, it determines the content of monoamine neurotransmitters and their major metabolites in the neostriatum in hemiparkinsonian monkeys. The hemiparkinsonian model in monkeys was induced by a unilateral intracarotid injection of methyl-phenyl-tetrahydropyridine (MPTP). Unencapsulated BCCs, BCCs microencapsulated in alginate-polylysine-alginate (ALA) membranes as well as empty microencapsules were grafted into the neostriatum of the hemiparkinsonian monkeys. Following the transplantation the hemiparkinsonian symptoms subsided and the number of rotations induced by apomorphine decreased for up to nine months in the group of recipients grafted with microencapsulated BCCs, while only a temporary improvement (one month) was detected in the recipients of the unencapsulated BCCs. No change was observed in the recipients of empty microencapsules. Dopamine and its metabolites were found considerably depleted in the MPTP-lesioned side versus the unlesioned side of the neostriatum in the hemiparkinsonian monkeys(P<0.05).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante Heterólogo
/
Células Cromafines
/
Trastornos Parkinsonianos
Límite:
Animals
Idioma:
En
Revista:
Artif Cells Blood Substit Immobil Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
/
TRANSPLANTE
Año:
2000
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Reino Unido