Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center.
Thromb Haemost
; 84(1): 93-7, 2000 Jul.
Article
en En
| MEDLINE
| ID: mdl-10928477
We evaluated the utility of the PFA-100 platelet function analyzer in identifying disorders in platelet function and/or von Willebrand factor (vWF) in patients with various systemic disorders being followed at a tertiary care center. Closure times were determined with collagen/ ADP (CADP) and collagen/epinephrine (CEPI) cartridges for 305 patients, and abnormal results were further evaluated with platelet aggregometry and vWF analysis. Prolonged CADP and/or CEPI closure times were identified in 114 patients (37.3%), but most were isolated prolonged CEPI closure times predominantly due to aspirin therapy (79 patients). Prolonged CADP closure times were most frequently due to qualitative platelet defects and/or decreased vWF levels. Prolonged CADP closure times were encountered most frequently in patients with sickle cell disease and were associated with a decreased hematocrit. This study demonstrated that the PFA-100 analyzer can accurately assess vWF-dependent platelet function and detect other platelet defects under high shear stress in complex patient populations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Servicio Ambulatorio en Hospital
/
Pruebas de Función Plaquetaria
/
Enfermedades de von Willebrand
/
Trastornos de las Plaquetas Sanguíneas
/
Hospitales Universitarios
Tipo de estudio:
Evaluation_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Thromb Haemost
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania