Participation of hippocampal metabotropic glutamate receptors, protein kinase A and mitogen-activated protein kinases in memory retrieval.
Neuroscience
; 99(1): 1-5, 2000.
Article
en En
| MEDLINE
| ID: mdl-10924946
The ability to recall past events is a major determinant of survival strategies in all species and is of paramount importance in determining our uniqueness as individuals. In contrast to memory formation, the information about the molecular mechanisms of memory retrieval is surprisingly scarce and fragmentary. Here we show that pretest inhibition of the specific upstream activator of mitogen-activated protein kinase kinase, or of protein kinase A in the hippocampus, blocked retrieval of long-term memory for an inhibitory avoidance task, a hippocampal-dependent learning task. An activator of protein kinase A enhanced retrieval. Mitogen-activated protein kinase activation increased in the hippocampus during retrieval, while protein kinase A activity remained unchanged. Pretest intrahippocampal blockade of metabotropic glutamate receptors or alpha-amino-3-hydroxy-5-methyl-4-isoxazolone propionic acid/kainate receptors, but not N-methyl-D-aspartate receptors or calcium/calmodulin dependent-protein kinase II, impaired retrieval. Thus, recall of inhibitory avoidance activates mitogen-activated protein kinase, which is necessary, along with metabotropic glutamate receptors, alpha-amino-3-hydroxy-5-methyl-4-isoxazolone propionic acid/kainate receptors, and protein kinase A, for long-term memory expression. Our results indicate that memory formation and retrieval may share some molecular mechanisms in the hippocampus.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recuerdo Mental
/
Receptores de Glutamato Metabotrópico
/
Proteínas Quinasas Dependientes de AMP Cíclico
/
Proteínas Quinasas Activadas por Mitógenos
/
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Neuroscience
Año:
2000
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Estados Unidos