[Evidence of the therapeutic effect of antihypertensive therapy: meta-analysis and meta-regression of randomized and controlled trials]. / Evidencia del efecto del tratamiento antihipertensivo: metaanálisis y metarregresión de ensayos controlados y aleatorizados.
Med Clin (Barc)
; 114 Suppl 2: 28-33, 2000.
Article
en Es
| MEDLINE
| ID: mdl-10916803
BACKGROUND: Meta-analysis is one of the most useful methodologies in evidence-based medicine. The goal of this paper is to introduce meta-analysis and meta-regression in the synthesis of scientific evidence in the efficacy of antihypertensive therapy. METHODS: Data from 13 randomized controlled trial comparing active antihypertensive therapy with a non-therapeutic control have been analyzed. Data on trials following patients at least more than one year have been poole through random-effects models and meta-regression models. RESULTS: Pooled data from meta-analysis showed that antihypertensive therapy decreased the risk of adverse outcomes attributable to the disease, mainly stroke. Regression models indicated that this risk was independent from study duration and patients mean age. CONCLUSIONS: The results of this study have showed the applicability and usefulness of data synthesis techniques in decision making in health care using hypertension as a case-study. This case-study allows us to make recommendations for research and therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipertensión
/
Antihipertensivos
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Guideline
/
Prognostic_studies
/
Systematic_reviews
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
Es
Revista:
Med Clin (Barc)
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
España