Assembly of the cellular powerhouse: current issues in muscle mitochondrial biogenesis.
Exerc Sport Sci Rev
; 28(2): 68-73, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10902088
Mitochondrial biogenesis occurs in muscle in response to chronic exercise, resulting in fatigue resistance. The assembly of the organelle is initiated by contraction-induced signals, which lead to the transcriptional activation of nuclear genes. This is accompanied by alterations in mRNA stability, as well as increases in protein import and mitochondrial DNA copy number, leading to a greater muscle mitochondrial content.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Músculo Esquelético
/
Mitocondrias Musculares
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Exerc Sport Sci Rev
Año:
2000
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos