[Certain biochemical blood markers in the process of cholinergic therapy in Alzheimer's disease]. / Nekotorye biokhimicheskie pokazateli krovi v protsesse kholinergicheskoi terapii pri bolezni Al'tsgeimera.
Zh Nevrol Psikhiatr Im S S Korsakova
; 100(6): 29-32, 2000.
Article
en Ru
| MEDLINE
| ID: mdl-10900685
Acetylcholinesterase (AChE) activity and parameters of the system of regulation of lipid peroxidation (LPO) were estimated in blood of patients with Alzheimer's disease (AD) during therapy with amiridine and gliatiline. It was found that the therapy was accompanied by inhibition of AChE activity. A significant correlation was observed between clinical efficiency and changes of AChE activity. AD was characterised by essential changes in LPO parameters: the level of the primary products of oxidation was increased three times with a sharp increase (seven times) of total unsaturation of lipids. A significant correlation was found between AChE activity and the level of the primary products of oxidation in blood erythrocytes of AD patients before and after therapy with amiridine and gliatiline.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inhibidores de la Colinesterasa
/
Fármacos Neuroprotectores
/
Enfermedad de Alzheimer
/
Aminoquinolinas
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Zh Nevrol Psikhiatr Im S S Korsakova
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2000
Tipo del documento:
Article
Pais de publicación:
Rusia