An antimalarial stilbene from Artocarpus integer.

Boonlaksiri, C; Oonanant, W; Kongsaeree, P; Kittakoop, P; Tanticharoen, M; Thebtaranonth, Y

Boonlaksiri, C; Oonanant, W; Kongsaeree, P; Kittakoop, P; Tanticharoen, M; Thebtaranonth, Y.

Afiliación

Boonlaksiri C; Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

Phytochemistry ; 54(4): 415-7, 2000 Jun.

Article en En | MEDLINE | ID: mdl-10897483

RESUMEN

Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 micrograms/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene , were also isolated. Structures of these compounds were deduced on the basis of their spectral data.

Asunto(s)

Antimaláricos/aislamiento & purificación; Plantas Medicinales/química; Estilbenos/aislamiento & purificación; Animales; Antimaláricos/química; Antimaláricos/farmacología; Espectroscopía de Resonancia Magnética; Estructura Molecular; Plasmodium falciparum/efectos de los fármacos; Espectrometría de Masa por Ionización de Electrospray

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Estilbenos / Antimaláricos Límite: Animals Idioma: En Revista: Phytochemistry Año: 2000 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido

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