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Contribution of PET studies in diagnosis of corticobasal degeneration.
Lutte, I; Laterre, C; Bodart, J M; De Volder, A.
Afiliación
  • Lutte I; Neurology Service, Cliniques St. Luc, Louvain-en-Woluwe, Belgium.
Eur Neurol ; 44(1): 12-21, 2000.
Article en En | MEDLINE | ID: mdl-10894990
Five patients with clinical features of corticobasal degeneration (CBD) were studied with PET imaging. The main clinical findings included a unilateral extrapyramidal motor disorder, without significant response to levodopa, as well as clumsiness, dysarthria, apraxia and a clear asymmetry of neurological signs. PET studies with (18)F-labeled 2-deoxy-2-fluoro-D-glucose disclosed mainly a significant hypometabolism in the thalamus and motor cortex controlateral to the more affected limbs. Additional relationships between individual clinical signs and PET data were also found. We concluded that PET findings supported the clinical diagnosis of CBD, although the specific pattern related to this condition needs to be more precisely defined. Further studies are especially needed to correlate clinical data and PET results with pathological examination.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Tomografía Computarizada de Emisión / Corteza Cerebral / Enfermedades Neurodegenerativas Tipo de estudio: Diagnostic_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Eur Neurol Año: 2000 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Tomografía Computarizada de Emisión / Corteza Cerebral / Enfermedades Neurodegenerativas Tipo de estudio: Diagnostic_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Eur Neurol Año: 2000 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza