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TSH and cAMP do not signal mitogenesis through Ras activation.
Van Keymeulen, A; Roger, P P; Dumont, J E; Dremier, S.
Afiliación
  • Van Keymeulen A; Institute of Interdisciplinary Research (IRIBHN), Université Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, Brussels, B-1070, Belgium. avkeymeu@ulb.ac.be
Biochem Biophys Res Commun ; 273(1): 154-8, 2000 Jun 24.
Article en En | MEDLINE | ID: mdl-10873578
Ras activation by receptor tyrosine kinases or serpentine receptors is generally considered to be essential for G1 phase progression and mitogenesis. In the physiologically relevant model of primary dog thyrocytes, the accumulation of the GTP-bound form of Ras constituted an early convergence point of various mitogenic or comitogenic stimuli including EGF, HGF, phorbol esters, insulin and carbachol. By contrast, the basal level of GTP-Ras was slightly reduced by TSH and forskolin and did not increase during the TSH/cAMP-dependent progression into G1 phase. This rules out a role for the activation of Ras as a signal in the mitogenesis elicited by TSH via cAMP in these cells.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirotropina / AMP Cíclico / Proteínas ras / Mitógenos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2000 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirotropina / AMP Cíclico / Proteínas ras / Mitógenos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2000 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos