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DNA fingerprinting of a national sample of Mycobacterium tuberculosis isolates, Botswana, 1995-1996.
Lockman, S; Sheppard, J D; Mwasekaga, M; Kenyon, T A; Binkin, N J; Braden, C R; Woodley, C L; Rumisha, D W; Tappero, J W.
Afiliación
  • Lockman S; Division of TB Elimination, National Centers for HIV/AIDS, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Int J Tuberc Lung Dis ; 4(6): 584-7, 2000 Jun.
Article en En | MEDLINE | ID: mdl-10864192
DNA fingerprinting may be useful to elucidate tuberculosis (TB) transmission in community settings, but its utility is limited if only few fingerprint patterns are observed or band numbers are low. We performed DNA fingerprinting on a national, population-based sample of Mycobacterium tuberculosis isolates from Botswana. During 1995-1996, a random sample of 213 isolates, representing 5% of all smear-positive TB cases, underwent DNA fingerprinting using restriction fragment length polymorphism (RFLP) IS6110 analysis. Eighty-two (38%) of the 213 isolates belonged to one of 18 clusters, with 2-9 isolates/cluster. The median number of bands was 10 (range 1-19); 183 (86%) had six or more bands. Sixty-three (49%) of 128 patients tested were infected with the human immunodeficiency virus (HIV). The degree of RFLP pattern heterogeneity and high band number support the feasibility of a prospective DNA fingerprinting study in Botswana.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dermatoglifia del ADN / Mycobacterium tuberculosis Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Int J Tuberc Lung Dis Año: 2000 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dermatoglifia del ADN / Mycobacterium tuberculosis Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Int J Tuberc Lung Dis Año: 2000 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia