Role of CD47 as a marker of self on red blood cells.
Science
; 288(5473): 2051-4, 2000 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-10856220
The immune system recognizes invaders as foreign because they express determinants that are absent on host cells or because they lack "markers of self" that are normally present. Here we show that CD47 (integrin-associated protein) functions as a marker of self on murine red blood cells. Red blood cells that lacked CD47 were rapidly cleared from the bloodstream by splenic red pulp macrophages. CD47 on normal red blood cells prevented this elimination by binding to the inhibitory receptor signal regulatory protein alpha (SIRPalpha). Thus, macrophages may use a number of nonspecific activating receptors and rely on the presence or absence of CD47 to distinguish self from foreign. CD47-SIRPalpha may represent a potential pathway for the control of hemolytic anemia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Receptores Inmunológicos
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Proteínas Portadoras
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Antígenos de Diferenciación
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Antígenos CD
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Autotolerancia
/
Moléculas de Adhesión de Célula Nerviosa
/
Molécula L1 de Adhesión de Célula Nerviosa
/
Eritrocitos
/
Macrófagos
Límite:
Animals
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Female
/
Humans
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Male
Idioma:
En
Revista:
Science
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos