Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.

Sen, T; Abdul Salam, C A; Pal, S; Sen, S; Nag Chaudhuri, A K

Sen, T; Abdul Salam, C A; Pal, S; Sen, S; Nag Chaudhuri, A K.

Afiliación

Sen T; Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.

Life Sci ; 66(23): PL325-30, 2000.

Article en En | MEDLINE | ID: mdl-10855953

RESUMEN

Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation. Antisecretory studies in pyloric ligated rats revealed that the drug at a dose of 100 mg/kg significantly reduced total acidity, gastric output and protein content. In another set of experiments, dothiepin significantly reduced gastric output, total acidity and protein content in pyloric ligated rats which received 50% alcohol (v/v) 30 minutes after the administration of dothiepin.

Asunto(s)

Antidepresivos Tricíclicos/uso terapéutico; Dotiepina/uso terapéutico; Eicosanoides/fisiología; Úlcera Gástrica/prevención & control; Animales; Antiinflamatorios no Esteroideos; Aspirina; Etanol; Indometacina; Ligadura; Masculino; Píloro/fisiología; Ratas; Restricción Física; Úlcera Gástrica/inducido químicamente; Úlcera Gástrica/etiología; Estrés Psicológico/complicaciones

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera Gástrica / Eicosanoides / Dotiepina / Antidepresivos Tricíclicos Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2000 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos

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