Inhibition of serine proteases by anti-inflammatory triterpenoids.
Planta Med
; 66(3): 206-10, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10821043
The lupane triterpenoid lupeol, the ursane triterpenoid alpha-amyrin and esters of these compounds are present in the bark of roots of Alstonia boonei (Apocynaceae) and have anti-inflammatory properties. alpha-Amyrin is a competitive inhibitor of bovine trypsin and chymotrypsin (Ki values 29 microM and 18 microM, respectively). Lupeol linoleate, lupeol palmitate and alpha-amyrin linoleate are non-competitive inhibitors of trypsin (Ki values 7 microM, 10 microM and 16 microM, respectively). alpha-Amyrin linoleate is also a non-competitive inhibitor of chymotrypsin (Ki value 28 microM). Lupeol is a competitive inhibitor of both trypsin and chymotrypsin (Ki values 22 and 8 microM, respectively). alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki 6 microM). Lupeol, alpha-amyrin and the palmitic and linoleic acid esters of these compounds are ineffective or very weak as inhibitors of porcine pancreatic elastase and of Lucilia cuprina and Helicoverpa punctigera leucine aminopeptidases. These hydrophobic triterpenoids represent further examples of anti-inflammatory triterpenoids that are PKA inhibitors as well as being selective protease inhibitors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Inhibidores de Serina Proteinasa
/
Antiinflamatorios no Esteroideos
Límite:
Animals
Idioma:
En
Revista:
Planta Med
Año:
2000
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Alemania