Enhanced cytogenetic and antitumor effects by 9-nitrocamptothecin and antineoplastics.
Teratog Carcinog Mutagen
; 20(3): 141-6, 2000.
Article
en En
| MEDLINE
| ID: mdl-10820424
Enhanced sister chromatid exchange (SCE) frequency by either melphalan (Mel) or epirubicin (Epir) was observed when human lymphocytes were exposed in vitro to 9-nitro-20(S)-camptothecin (9NC). A correlation was observed between the magnitude of the SCE response and the depression of the cell proliferation index. The antitumor activity of Mel and of 9NC was tested on leukemia P-388-bearing mice. The two chemicals in combination enhance antitumor activity in a synergistic manner. Therefore, the in vivo antitumor effect of Mel in conjunction with 9NC appears to correlate well with the in vitro synergistic effect on SCE induction caused by the combined Mel plus 9NC treatment. Teratogenesis Carcinog. Mutagen. 20:141-146, 2000.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Intercambio de Cromátides Hermanas
/
Camptotecina
/
Linfocitos
/
Epirrubicina
/
Leucemia P388
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Melfalán
/
Antineoplásicos Fitogénicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Teratog Carcinog Mutagen
Año:
2000
Tipo del documento:
Article
País de afiliación:
Grecia
Pais de publicación:
Estados Unidos