In vitro activities of membrane-active peptides alone and in combination with clinically used antimicrobial agents against Stenotrophomonas maltophilia.

Giacometti, A; Cirioni, O; Del Prete, M S; Barchiesi, F; Fortuna, M; Drenaggi, D; Scalise, G

Giacometti, A; Cirioni, O; Del Prete, M S; Barchiesi, F; Fortuna, M; Drenaggi, D; Scalise, G.

Afiliación

Giacometti A; Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy. cmalinf@popcsi.unian.it

Antimicrob Agents Chemother ; 44(6): 1716-9, 2000 Jun.

Article en En | MEDLINE | ID: mdl-10817738

RESUMEN

The in vitro activities of buforin II, cecropin P1, and magainin II, alone and in combination with six clinically used antimicrobial agents, against 12 clinical isolates of Stenotrophomonas maltophilia were investigated. Antimicrobial activities were measured by MIC and time-kill studies. The isolates were susceptible to the peptides at concentrations in the range of 0.50 to 16 microg/ml. Synergy was observed when the peptides were combined with polymyxin E, meropenem, ceftazidime, piperacillin, and clarithromycin.

Asunto(s)

Antibacterianos/farmacología; Péptidos Catiónicos Antimicrobianos; Stenotrophomonas maltophilia/efectos de los fármacos; Proteínas de Xenopus; Ceftazidima/farmacología; Colistina/farmacología; Sinergismo Farmacológico; Magaininas; Meropenem; Péptidos/farmacología; Piperacilina/farmacología; Proteínas/farmacología; Tienamicinas/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Stenotrophomonas maltophilia / Péptidos Catiónicos Antimicrobianos / Proteínas de Xenopus / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Año: 2000 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

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