[Degradation of phosphatidylnucleosides induced by phospholipases].

Novozhilova, T I; Malekin, S I; Kozhukhov, V I; Krugliak, Iu L; Kurochkin, V K

[Degradation of phosphatidylnucleosides induced by phospholipases]. / Rasshcheplenie fosfatidilnukleozidov pod deistviem fosfolipaz.

Novozhilova, T I; Malekin, S I; Kozhukhov, V I; Krugliak, Iu L; Kurochkin, V K.

Afiliación

Novozhilova TI; State Research Institute of Organic Chemistry and Technology, Moscow, Russia.

Bioorg Khim ; 26(3): 238-40, 2000 Mar.

Article en Ru | MEDLINE | ID: mdl-10816823

RESUMEN

Hydrolysis of phosphatidylnucleosides, 5'-(rac-1-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoryl)-3'-azido- 3'-deoxythymidine and -2',3'-didehydro-3'-deoxythymidine, effected by phospholipases (PL) A2, C, and D was studied to reveal the metabolism of these derivatives. It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides.

Asunto(s)

Didesoxinucleósidos/química; Ácidos Fosfatidicos/química; Fármacos Anti-VIH/química; Hidrólisis; Fosfolipasa D/química; Fosfolipasas/química; Fosfolipasas A/química; Fosfolipasas A2; Especificidad por Sustrato; Fosfolipasas de Tipo C/química

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Fosfatidicos / Didesoxinucleósidos Idioma: Ru Revista: Bioorg Khim Año: 2000 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia

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