Myelointegration of titanium implants: B lymphopoiesis and hemopoietic cell proliferation in mouse bone marrow exposed to titanium implants.
Int J Oral Maxillofac Implants
; 15(2): 175-84, 2000.
Article
en En
| MEDLINE
| ID: mdl-10795449
Multinucleated giant cells have been observed at interfaces between bone marrow and titanium implants in mouse femurs. This raises concern that macrophage-derived factors might perturb local lymphohemopoiesis, possibly even predisposing to neoplasia in the B lymphocyte lineage. It has been found that an implant-marrow interface with associated giant cells persists for at least 1.5 years. Precursor B cells show early increases in number and proliferative activity. At later intervals, however, they do not differ significantly from controls, and there are no perturbations in spatial localization of either B lineage cells or DNA-synthesizing hemopoietic cells. The results of this investigation in mice demonstrate that, following initial marrow regeneration and fluctuating precursor B cell activity, and despite the presence of giant cells, titanium implants apparently become well-tolerated by directly apposed bone marrow cells in a lasting state of "myelointegration."
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Titanio
/
Materiales Biocompatibles
/
Células de la Médula Ósea
/
Células Madre Hematopoyéticas
/
Linfocitos B
/
Implantes Dentales
/
Oseointegración
/
Leucopoyesis
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Int J Oral Maxillofac Implants
Asunto de la revista:
ODONTOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos