Transient over-expression of NGFI-A gene suppresses NGF-induced neurite outgrowth in PCI2 cells.
Neuroreport
; 11(5): 1001-5, 2000 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-10790872
Using an inducible gene expression system (Tet-ON system), the role of NGFI-A gene during the neuronal differentiation of PCI2 cells was examined. When NGFI-A was transiently over-expressed, no obvious effects on cell proliferation or neurite outgrowth were observed. Interestingly, however, NGFI-A over-expression resulted in significant retardation in NGF-induced neurite outgrowth. Similar suppressive effects were observed also on the v-K-ras-induced neurite outgrowth. These results raise the possibility that NGFI-A protein may play some negative role in NGF signaling.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Neuritas
/
Proteínas Inmediatas-Precoces
/
Regulación del Desarrollo de la Expresión Génica
/
Factor de Crecimiento Nervioso
/
Proteínas de Unión al ADN
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido