Measurement of thrombopoietic levels: clinical and biological relationships.
Curr Opin Hematol
; 7(3): 143-9, 2000 May.
Article
en En
| MEDLINE
| ID: mdl-10786650
Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a translational mechanism was recently appreciated as the cause for hereditary thrombocythemia and will have to be elucidated in other conditions of thrombocytosis in association with increased TPO levels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trombopoyetina
/
Proteínas de Neoplasias
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Animals
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Curr Opin Hematol
Asunto de la revista:
HEMATOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos