Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure.

Wagoner, L E; Craft, L L; Singh, B; Suresh, D P; Zengel, P W; McGuire, N; Abraham, W T; Chenier, T C; Dorn, G W; Liggett, S B

Wagoner, L E; Craft, L L; Singh, B; Suresh, D P; Zengel, P W; McGuire, N; Abraham, W T; Chenier, T C; Dorn, G W; Liggett, S B.

Afiliación

Wagoner LE; Department of Medicine, Divisions of Cardiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0542, USA. Wagonele@ucmail.uc.edu

Circ Res ; 86(8): 834-40, 2000 Apr 28.

Article en En | MEDLINE | ID: mdl-10785504

RESUMEN

The beta(2)-adrenergic receptor (beta(2)AR) exists in multiple polymorphic forms with different characteristics. Their relevance to heart failure (HF) physiology is unknown. Cardiopulmonary exercise testing was performed on 232 compensated HF patients with a defined beta(2)AR genotype. Patients with the uncommon Ile164 polymorphism had a lower peak VO(2) (15.0+/-0.9 mL. kg(-1). min(-1)) than did patients with Thr164 (17.9+/-0.9 mL. kg(-1). min(-1), P<0.0001). The percentage achieved of predicted peak VO(2) was also lower in patients with Ile164 (62. 3+/-4.5% versus 71.5+/-5.1%, P=0.045). The relative risk of a patient having a VO(2)

Asunto(s)

Ejercicio Físico; Insuficiencia Cardíaca/genética; Insuficiencia Cardíaca/fisiopatología; Polimorfismo Genético; Receptores Adrenérgicos beta 2/genética; Alelos; Femenino; Predisposición Genética a la Enfermedad; Humanos; Masculino; Persona de Mediana Edad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Ejercicio Físico / Receptores Adrenérgicos beta 2 / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Circ Res Año: 2000 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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