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Reduced basal and stimulated leukocyte adherence in tumor endothelium of experimental pancreatic cancer.
Schmidt, J; Ryschich, E; Maksan, S M; Werner, J; Gebhard, M M; Herfarth, C; Klar, E.
Afiliación
  • Schmidt J; Department of Surgery, University of Heidelberg, Germany.
Int J Pancreatol ; 26(3): 173-9, 1999 Dec.
Article en En | MEDLINE | ID: mdl-10732294
BACKGROUND: The interaction between immunocompetent cells and tumor endothelium is essential for an effective immunological response. In the present study, we evaluated resting and CD11b/CD18-mediated leukocyte adhesion in tumor vessels of experimental pancreatic cancer and in healthy pancreatic venules in the rat. METHODS: Solid tumor fragments (1 mm3) were interposed intrapancreatically between inert transparent polymethylmetacrylate plates for intravital microscopy (n = 12) by which tumor microcirculation, leukocyte-tumor-endothelium interaction, and the effect of the chemoattractants N-formyl-methioninleucylphenylalanine (fMLP) and platelet-activating factor (PAF) on leukocyte adherence was investigated. RESULTS: Leukocyte adhesion in pancreatic tumor vessels was significantly reduced compared to healthy pancreatic venules. Both fMLP and PAF dramatically increased leukocyte adherence in normal pancreatic venules. No change in leukocyte adhesion was present in tumor vessels after exposure to these chemotactic substances. CONCLUSION: Resting and stimulated integrin-dependent leukocyte adhesion is strongly reduced in malignant vessels of experimental pancreatic cancer, which may be an important mechanism to escape immune control.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma / Endotelio / Leucocitos Límite: Animals Idioma: En Revista: Int J Pancreatol Asunto de la revista: GASTROENTEROLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma / Endotelio / Leucocitos Límite: Animals Idioma: En Revista: Int J Pancreatol Asunto de la revista: GASTROENTEROLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos